The life of a lonesome caretaker (Toni Collette) is turned upside down when she stumbles upon the body of a murdered girl. This discovery may provide closure for a forensics graduate student (Rose Byrne) whose sister went missing when she was a child. A housewife (Mary Beth Hurt) makes a disturbing connection between the body and her own husband (Nick Searcy) which leads her to take dark and decisive action. A mother (Marcia Gay Harden) desperately searches for answers about her runaway daughter's life and finds answers in one of her troubled young friend (Kerry Washington). A volatile young woman (Brittany Murphy) goes on an odyssey to get a birthday present to her little girl. Together, these stories paint a devastating portrait of seven women whose lives are linked by a single act of violence and a desire for change.